Amani Nabil Shafik

Professor of Medical Pharmacology
Faculty of Medicine - Cairo University

Nationality: Egyptian.

Date of Birth:  3/5/1967.

Place of Birth: Cairo, Egypt.

Address: 74 A Teret El Zomor street- Haram- Giza- Egypt.

Position: Professor of Medical Pharmacology, Faculty of Medicine- Cairo University.

Tel:    +(202) 35863322                                             Cell :  +20 (12) 23507023

E-mail: nabilamani123@hotmail.com               amaninabil@kasralainy.edu.eg

Languages:  Arabic, English & French

                                                         

Qualifications:

●M.B.,B.CH. December, 1990 (signed up “Excellent with Honours”)- Faculty of Medicine- Cairo University. 

●M.SC. Degree in Clinical and Chemical Pathology, November, 1994 (singed up “Good”)- Faculty of Medicine- Cairo University.

●M.SC. Degree in Basic Medical Science (Pharmacology), May, 1996 (singed up “Excellent”)- Faculty of Medicine- Cairo University.

●M.D. Degree in Medical Pharmacology, May, 1999- Faculty of Medicine- Cairo University.

Professional Background:-

●Demonstrator of Pharmacology, Faculty of Medicine- Cairo University, from  4/7/1994 to 1/10/1996.
●Assistant lecturer of Pharmacology, Faculty of Medicine- Cairo University, from 2/10/1996 to  28/9/1999.
●Lecturer of Pharmacology, Faculty of Medicine- Cairo University, from 29/9/1999. 
●Assistant Professor of Pharmacology, Faculty of Medicine- Cairo University, from 22/2/2006 till 22/1/2013.  
●Professor of Medical Pharmacology, Faculty of Medicine- Cairo University, from 23/1/2013 till now.  

Position:

 -Professor of Medical Pharmacology, Faculty of Medicine, Cairo University

-Vice director of The Clinical Research Center, Medical Pharmacology Department, Faculty of Medicine, Cairo University

- Coordinator of Cairo University Ethics Committee for the Care and Use of Experimental Animals in Education and Scientific Research (CU-IACUC)

Training Courses:-

-House Officer, Kasr El-Eini Hospital - Faculty of Medicine- Cairo University, from 1/3/1991 to  31/12/1991.
-House Officer, National Cancer Institute-Cairo University, from 1/1/1992 to  28/2/199

-Resident in the Department of Clinical and Chemical Pathology, Faculty of Medicine-Cairo University, from 1/3/1992 to 3 /7/1994.

Courses for Staff Development on:

- Evaluation of teaching, March 2006
- Methods of Scientific Research, March 2006
- Concepts of quality in teaching. november 2008
- Scientific Puplication. February 2010
- Use of Technology in Teaching. June 2010
-Time and Conference Management. December 2010
- Communication skills. April 2011
- Students Evaluation.  October 2011

Workshop on:-

- Curriculum Revision. November 2007

- Medical education reform “ theory & practice”. 2008

- PowerLab in Teaching & Research Workshop, 2008.

- The concepts of Quality in teaching, 2009.

- Curriculum Update by Professors from University of Sheffield. June 2009

- Introduction of portfolios in postgraduate and faculty assessment. June 2009        

- Integrative and Organ System Pharmacology (IOSP) of Cardiovascular drugs.2010

- Integration in Medical Education. January 2010

- Integration in Medical Education. March 2010

- Time-Based Learning. December 2010

- International Clinical Trials. January 2011

- Program report. June 2011

- Fundamentals of Clinical Trial Management” , 2016

Conferences

-The Ninth Annual Kasr El-Aini Medical Congress, 25-28 February 1997.

-The Tenth Annual Kasr El-Aini Medical Congress, 4-6 March 1998.

-The Second Annual Scientific Conference on Drug- Abuse, 8 October 1998.

-The Annual Kasr El-Aini Medical Congress, 15-17 February 2000.

-43rd Conference of Egyptian Society of Pharmacology and Experimental Therapeutics, Suez Canal University, 23 November 2000.

- The Annual Kasr El-Aini Medical Congress, 3-5 April 2001.

-45rd Annual Conference of Egyptian Society of Pharmacology and Experimental Therapeutics, 27-28 April 2002. 

-The 5th Annual Kasr El-Aini Medical Congress, 2-4 March 200.

-The Annual Kasr El-Aini Medical Congress, 31March to 1st of April 2004

-Internal Medical Scientific Conference. May 2007

-Medical Education Reform. Theory and Practice. November 2008.

-The Egyptian Society of Basic Medical Science. March 2009.

-The 10th Regional Annual Assembly Meeting of the Egyptian Scientific Society of Bronchology (ESSB) in Collaboration with the Egyptian Fellows of the American College of Chest Physicians (ACCP). 1-3 December 2010. Speaker  on Patient's Education in Chest Disease, lecture for Pharmacists.

-The second Training Course for Pharmacolgy and Clinical Pharmacy. 18-20 December 2010

- Conference of Pharmacology Department in Faculty of Medecine Cairo University. June 2011

- Conference of the Egyptian Society for Pharmacology and Experimental Therapeutics "Teaching and Research in Basic and Clinical Pharmacology”. Mars 2012

- Conference of Pharmacology Dep

artment in Faculty of Medecine Cairo University. April 2013

- The Annual Kasr El-Aini Medical Congress. April 2013

- Emergency in Egypt- kasr Al Ainy History and Future, May 2015

- 

The Annual Kasr El-Aini Medical Congress. May 2016

   Title of my Thesis:-

●M.SC. of Clinical and Chemical Pathology:-
Beta-2-Microglobulin as a Possible Marker of CNS Involvement in Acute Leukemia.
●M.SC.  of  Pharmacology:-
Pharmacological Studies of Some of the Adverse Effects of Perindopril.
●M.D.  of  Pharmacology:-
Effect of Fosinopril on Some Serum Constituents in Experimentally Induced Diabetes Mellitus in Rats.

  Thesis I had supervised:-

Master Degree in Pharmacology
1. "Some Agents Modulating Experimental Streptozotocin-Induced Diabetes Mellitus in Rats". 
2."Effects of Androgen and Estrogen Therapy on Bone Minerals and Histomorphometric Changes in Experimentally Induced Osteoporosis in Male and Female Rats". 
3. "Potential Beneficial Effects of Verapamil on Liver fibrosis in Rats".
4. “Effects of Nebivolol, Carvedilol and Metoprolol on Doxorubicin-induced cardiotoxicity in Rats”. 
5. "Pharmacological Effects of Ivabradine on Induced Myocardial Ischemia in Rats". 
6. "Study of the anti-inflammatory Activity of Roxithromycin [macrolide antibiotic] in some animal models".
7. "Study of the Possible Mechanisms of action of Atorvastatin in an air-pouch model of Inflammation induced in rats".
8. "Experimental study of the possible role of lovastatin in bronchial asthma".
9. “Effect of lisinopril, ramipril and their combinations with aspirin on systemic hypertension and hemostatic profile in albino rats”.
10. “Study of the mechanism of action of verapamil in prevention of β-cell apoptosis in STZ-induced Diabetes in rats”.

11. “Effect of Dexamethasone alone and combined with sildenafil on monocrotaline-induced pulmonary hypertension in rats”.

12. “Possible memory protective role of simvastatin and insulin in an experimental rat model of diabetes mellitus and dementia”.

13. Role of two xanthine oxidase inhibitors "allopurinol and febuxostat" in metabolic syndrome induced experimentally in rats.

14. Role of Esomeprazole and Magnesium sulfate in Pre-eclampsia induced experimentally in rats.

15. The Protective Role of Insulin  Alone, in Combination with Metformin or Sitagliptin Against Early Cardiac Dysfunction in Streptozotocin-Induced Diabetic Rats.

 

MD Degree in Pharmacology 
1. "The Potential Pharmacological Preconditioning Effect of Monophosphoryl Lipid A in Induced  Myocardial Ischemia in Rats". 
2. "A pharmacovigilance study on patients with obstructive airway diseases admitted in Kasr-Alaini teaching hospital".
3. "Study of the osteogenic and cardiovascular effects of mono and combined administration of growth hormone and simvastatin to ovariectomized rats".

4. The role Of Mosapride and Levosulpiride in gut function and glycemic control in diabetic rats. 

    Research Experience & Publications

1. Studies on Streptozotocin Diabetes. Effect of Streptozotocin [variable doses, duration, with and without insulin treatment} on Blood Glucose, Pathology in Pancreas (beta- cell count) in Rats. Amani Nabil and Magdi Francis.
- J. Egypt. Soc. Pharmacol. Exp. Ther., Vol. 21, No. 1, Jan 2002.

2. Some Agents Modulating Experimental Streptozotocin-Induced Diabetes Mellitus in Rats. Shereen M. Rafai, Amani N. Shafik, Soha A. El-Morsy, Hedayat M. Tolba, Olfat Shaker, Sahar M. Talaat.
- Kasr El Eini Medical Journal Vol.,8, No1, January. 2002.

3. Modulatory Effect of L- arginine {Nitric Oxide Precursor} on Aspirin-Induced Changes in Gastric Mucosa and Motility in Rats. Hesham M. Mahmoud, Amani N. Shafik, Magdy I. Attalah, Magdy Mourad.
 - Medical Journal of Cairo University, vol. 3, 2003.

4. Effects of Androgen and Estrogen Therapy on Bone Minerals and Histomorphometric Changes in Experimentally Induced Osteoporosis in Male and Female Rats. Hayam A. Abd El Kawy, Amal A. Mishriki, Amani N. Shafik, Khaled A. Abd EL Azim.
- Kasr El Eini Medical Journal Vol., 9, No 3, May. 2003.

5. Preconditioning Modulates Susceptibility to Ischemia-Induced Changes in the Rat Heart in Vivo: The Role of Alpha- and Beta- Adrenergic Receptors. Amani N. Shafik and Maged A. Zikri. 
- The Egyptian Journal of Internal Medicine. Vol., 15, No 4, October. 2003.

6. The Use of Fluvastatin in Hypercholesterolemic Rats to Potentiate the Immuno-suppressive Effect of Cyclosporin and minimize its Renal Damaging Effect. Amani N. Shafik, Mohamed S. El Gendy and Bassem G. Fahmy.
- Bull. Egypt. Soc. Physiol. Sci. 24 (1) 2004.

7. Effect of  Sufentanil versus Fentanyl on the contraction of the pregnant human uterus. Experimental and clinical correlation. Ashraf Mounir, Amani N. Shafik, Reda R. Ismail
- Bull. Egypt. Soc. Physiol. Sci. 24 (1) 2004.

8. Preliminary Study on the Antimicrobial activity of some Non-Steroid Anti-inflammatory Drugs against Organisms Causing Arthritis. Hedayet Mahmoud Tolba and Amani Nabil Shafik.
- Kasr El Eini Medical Journal Vol., 7, No 2, May. 2001.

9. Assessment of Inotropic Therapy for Hypotensive Critically Ill Preterm Infants. Mohamed H. Sayed, Nashwa M.Samra, Moataza M. Basheer and Amani N. Shafik.
- Journal of Arab Child .Volume 15, Number 2, Apr., 2004.

10. Effects of Low-Molecular-Weight Heparin "Enoxaparin"  Versus Unfractionated Heparin "Heparin Sulphate" on vascular reactivity. Both Experimental and Clinical Studies. Amani N. Shafik, Ashraf Mounir
- Bulletin of Egyptian Society for Physiological Sciences. 25 (2) 2005.

11. The Potential Preconditioning Effect of Monophosphoryl Lipid A in Induced Myocardial Ischemia in Rats. Amani N. Shafik, Ebtissam Abd-EL Ghafar, Afaf S. Othman and Akram M. Nooh
- The Egyptian Society of Basic Medical Science (CAIRO). Volume 30, Number 1, June. 2009.

12. Role of ivabradine in vivo myocardial ischemia and reperfusion injuries induced in rats. Amani Nabil Shafik, Hisham A. Awad, Mary E. Attia and Ahmed Soliman.
- The Medical Journal of Cairo University.  March 2011. Volume 79, number 2. 

13. The effect of different dosage regimens of roxithromycin on its anti-inflammatory activity and possible mechanisms of action in acute pleurisy and chronic arthritis in rats. Amani Nabil Shafik, Soheir Abu Elazm Diab, Eman Abdel Moneim Abdel Rasheed ,Hanan Fouad, Safenaz Salahel Din, Eman Hassan Abd Elrahman
- The Medical Journal of Cairo University.  June 2011. Volume 79, number 1. 

14.Improved antifibrotic effect of a combination of verapamil and silymarin in rat-induced liver fibrosis. Amani N., Shafik, Mostafa M., Khodei , Nadia A., Gouda , Mohamed E., Mahmoud
- Arab Journal of Gastroenterology, 12 (2011) 143–149.

15. Effects of topiramate on diabetes induced by streptozotocin in rats. Amani Nabil Shafik.                                                 -European journal of Pharmacology. 684 (2012) 161–167.

         
16. The HMG-CoA reductase inhibitor "atorvastatin" reduces air pouch inflammation by different mechanisms. Amani Nabil Shafik, Hisham Attia Awad, Mostafa Mahmoud Khodeir, Jamal Mohamed Dammona.
- The Medical Journal of Cairo University.  Vol. 80, No. 2, September 2012

17.Febuxostat improves the local and remote organ changes induced by intestinal ischemia/reperfusion in rats.  Amani Nabil Shafik.
- Digestive Diseases and Sciences,   (2013) 58:650–659.

Teaching Activities and Areas of Responsibility

My job as a Professor of Pharmacology in the Department of Pharmacology, Faculty of Medicine , Cairo University entails fulfillment of the following responsibilities: 

1. Teaching lectures & tutorial classes for the third year medical students.

2. Teaching Pharmacology Courses for Medical Postgraduate Students.

3. Correction of exam papers.

4. Supervisor and 

Teaching the Pharmacology course for 3rd year Physical therapy students 

Cairo University .

5.

Teaching the Pharmacology course for 2nd year Dentistry students (Ahram Canadian University).

6.

Teaching the Basic Pharmacology course for 2nd year Dentistry students Cairo University.

6. Supervision of theses for fulfillment of  Master and M.D. degrees in Pharmacology and other specialties.

7. Conducting experimental research work in the Department of Pharmacology.

8. Drug Information Center service.

9. Auditing Clinical Sheets as part of clinical pharmacology program.

10. Training courses for the Pharmacist [under and post-graduate=PharmD]

Reviewer Experience

1.  African Journal of Biotechnology

2.   European Journal of Gastroenterology & Hepatology

3.    Mini-Reviews in Medicinal Chemistry

4.     Journal of Clinical Case Reports

5. Kasr Al Ainy Medical Journal

Editorial Board

Member in the editorial board of: 

-EC Gastroenterology and Digestive System

-EC Cardiology